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High FDA and WHO scientists reject COVID booster vaccinations

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Top scientists around the world – including experts from the FDA and the World Health Organization – opposed the need for widespread booster vaccinations against the coronavirus on Monday.

In a review published in the leading medical journal The Lancet, the scientists argued that booster vaccinations are not required in the general population because vaccines are still highly effective in preventing serious illness and death. They also mentioned the urgent need to give unvaccinated people doses around the world to save lives and prevent more dangerous variants from occurring.

The review comes as the U.S. nears the Biden government’s proposed launch date for booster adoption, which is recommended eight months after a person is given the Pfizer or Moderna COVID-19 vaccines for a second time. The report also comes a week after the White House announced a massive push to make vaccinations mandatory for nearly two-thirds of the U.S. workforce as bags of unvaccinated individuals continue to cause high hospital admissions and deaths across the country.

The 18 co-authors of the Lancet review include Marion Gruber, director of the FDA’s vaccines office, and Philip Krause, her deputy at the agency, both of whom announced their resignation in the fall in part because of their opposition to the refreshment of the Biden administration to plan. The review was also co-authored by several experts from the World Health Organization, which has called for a global moratorium on booster vaccinations to maximize vaccination globally – especially in developing countries where vaccination rates are very low.

The Lancet paper reviews the current knowledge about the protection that existing vaccines offer. Although the vaccines all offer less protection against infection with the delta variant compared to the previously dominant alpha, they still offer very good protection against serious illnesses. And while the ability to prevent infection or even symptomatic illness may decrease over time, protection against serious illness so far appears to be strong.

Three CDC reports released last week confirmed these results in most age groups and decreased more significantly in those aged 75 and over. One of the studies examined nearly 570,000 COVID-19 cases in the US from April to July and showed that unvaccinated people were almost five times more likely to be infected and more than ten times more likely to be hospitalized compared to people who received a vaccine become or die.

“Current evidence therefore does not appear to show a need for replenishment in the general population where efficacy against serious diseases remains high,” the Lancet authors write.

Data from Israel, which has already begun introducing booster vaccinations, showed increased protection against infections and serious illnesses after a third shot of the Pfizer vaccine, which was originally given in two doses. However, the Lancet authors noted that data was only collected for a week after the booster dose was given and it is unclear how long this protection lasts.

The Lancet authors argued that boosters might ultimately be needed as immunity wears off over time, but more research was needed to determine when it would be needed. At the moment, they argued, there is a more pressing need to give the existing doses to the unvaccinated. They also suggested that booster doses designed specifically against the major circulating variants of the coronavirus could be stronger and longer lasting.

“Even if some profit can ultimately be made from the top-up, it will not outweigh the benefits of initial protection for the unvaccinated,” the authors write. “If vaccines are used where they work best, they could hasten the end of the pandemic by stifling the further development of variants.”

Mike Ryan, director of WHO’s emergency health program, strongly condemned the introduction of booster vaccinations last month. “We plan to distribute extra life jackets to people who already have life jackets while drowning other people without a single life jacket,” said Ryan. “That’s the reality.”

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